The expression of matrix metalloproteinase-13 (MMP-13) on xenograft and PRF in bone regeneration

Objective: inflammation may play a role in bone loss by altering the remodelling process, favouring boneresorption osteoclasts over synthesis osteoblasts. Matrix metalloproteinase 13 (MMP-13) has abilityto activate osteoclasts, leading to resorption. Regenerative treatments have been widely used periodontology.When combined with Platelet-rich fibrin (PRF), xenografts will give better results regeneration. The aim ofthis study was evaluate effect of xenograft PRF on MMP-13 expression defect usingan experimentally created defect. Material and Methods: eighteen New Zealand rabbits were assigned threegroups. Each group consisted six rabbits. A critical diameter size 5 mm wascreated right tibia each rabbit 1 (application: xenograft), 2 PRF), 3(application: PRF). produced from ml blood taken rabbit’s ears. After 30 days,the euthanized. tissue samples evaluated immunohistochemical staining. Results: 3showed lowest mean (4.50) compared (20.50) (11.70). Group significant difference (P = 0.000) < 0.05).Conclusion: this research showed that combination had MMP-13.The application osteogenesis ability KEYWORDSMMP-13; Xenograft; fibrin; Bone regeneration; Inflammation.